hrp0082p2-d2-271 | Adrenals & HP Axis (1) | ESPE2014

The Results of CYP21A2 Mutation Analysis in Adolescent with Polycystic Ovary Syndrome

Yagli Colakoglu Elif , Bulus Derya , Andiran Nesibe , Ufuk Isin Ugur

Background: Diagnosis of polycystic ovary syndrome (PCOS) in the adolescent is difficult due to high background rate of menstrual irregularity, high prevalence of polycystic morphology and hyper and rogenic features in this population. Also late onset congenital adrenal hyperplasia (LOCAH) mimics PCOS in this period. It is important to distinguish these entities because of the differences in their therapy. The study aimed to find out the frequency of LOCAH in patients who diag...

hrp0082p3-d3-659 | Autoimmune Endocrine Disease | ESPE2014

Evaluation of the Relation between Thyroid Dysfunction and Oxidant/Antioxidant Status in Obese Children

Asci Ali , Bulus Derya , Andiran Nesibe , Kocer-Gumusel Belma

Background: Obesity has been defined as ‘abnormal or excessive fat accumulation that may impair health’ by World Health Organization.Objective and hypotheses: Although the role of oxidative stress in obesity has been interest of subject in recent studies, comprehensive studies evaluating parameters of oxidant/antioxidant status in children are limited. Moreover, there has been an increasing focus on the relationship between obesity and thyroid ...

hrp0082p3-d2-683 | Bone (1) | ESPE2014

Two Different Diagnosis of Pseudohypoaldosteronism

Bulus Derya , Andiran Nesibe , Colakoglu Elif Yagli , Altuntas Nilgun

Background: Pseudohypoaldosteronism (PHA) is a disorder caused by aldosterone resistance with impaired sodium reabsorption and potassium excretion from the body. PHA is subdivided into primary (genetic) and secondary (transient) forms. Primary PHA is caused by mutations in genes encoding epithelial sodium channel or mineralocorticoid receptors. The secondary PHA may occur due to urinary tract malformations, urinary tract infections (UTI), drugs, etc. We present here two cases ...

hrp0082p2-d1-537 | Puberty and Neuroendocrinology | ESPE2014

The Evaluation of Possible Role of Endocrine Disrupters in Precocious Puberty

Bulus Derya , Asci Ali , Andiran Nesibe , Kocer-Gumusel Belma , Colakoglu Elif Yagli

Background: Human health might be negatively affected by chemicals named as endocrine disrupters. Researchers showed that phthalates (bis-(2-ethylhexyl) phthalate (DEHP), mono-(2-ethylhexyl) phthalate (MEHP)) and bisphenol A (BPA) have an anti-androgenic and/or estrogenic effects. These endocrine disruptors are accused in occurrence and/or possible increase in unusual early puberty in girls in recent years.Objective and hypotheses: The aim of th...

hrp0084fc3.6 | Diabetes | ESPE2015

First Report of Nationwide Incidence and Prevalence of Type 1 Diabetes Among Children in Turkey

Yesilkaya Ediz , Cinaz Peyami , Andiran Nesibe , Bideci Aysun , Hatun Sukru , Sari Erkan , Turker Turker , Akgul Ozgur , Saldir Mehmet , Kilicaslan Huseyin , Acikel Cengizhan , Craig Maria

Background: Data on the epidemiology of type 1 diabetes among children in Turkey are limited.Objective and hypotheses: The aim of this study was to report, for the first time, the incidence and prevalence of childhood type 1 diabetes in Turkey using a nationwide registry.Method: Information on birth date, city of birth, diagnosis date and gender of all type 1 diabetes patients aged less than 18 years were obtained from the Turkish ...